The Whitesides Orthopaedic Research Laboratory

Scott D. Boden, MD
Director, The Whitesides Orthopaedic Research Laboratory

Dr. Boden’s basic research focus has centered on gaining an understanding of the biology of spine fusion healing and bone graft substitutes as well as the molecular control of bone formation and gene therapy applications for bone and intervertebral disc cartilage regeneration.  Work from this laboratory was instrumental in translating recombinant BMP-2 from pre-clinical studies to successful human clinical trials. The research is most recently focusing on the development of small molecules to promote bone and cartilage regeneration.  Dr. Boden is a named inventor on over 30 issued patents. 

Senior Scientists in the laboratory include Sreedhara Sangadala, PhD, Louisa Titus, PhD, and Manjula Viggeswarapu, PhD. In 2013, technology discovered in this laboratory under the leadership of Dr. Sangadala was licensed to SkelRegen, a start-up company spun out of Emory University with the goal of commercializing small molecule technologies to promote the next generation of skeletal tissue regeneration solutions.

Recent publications

Use of Recombinant Human Bone Morphogenetic Protein-2 With Local Bone Graft Instead of Iliac Crest Bone Graft in Posterolateral Lumbar Spine Arthrodesis. Park DK, Kim SS, Thakur N, Boden SD. Spine (Phila Pa 1976). 2013 Mar 7

A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair. Wong E, Sangadala S, Boden SD, Yoshioka K, Hutton WC, Oliver C, Titus L. J Bone Joint Surg Am. 2013 Mar 6;95(5):454-61

Natural antisense transcripts enhance bone formation by increasing sense IFITM5 transcription.Liu Y, Liu H, Titus L, Boden SD. Bone. 2012 Nov;51(5):933-8.

New treatments and imaging strategies in degenerative disease of the intervertebral disks. Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, Freemont A, Berven S, Sengupta DK, Tanenbaum L, Maurer P, Ranganathan A, Alavi A, Marinelli NL. Radiology. 2012 Jul;264(1):6-19

What's New in Spine Surgery. Bridwell KH, Anderson PA, Boden SD, Vaccaro AR, Wang JC. J Bone Joint Surg Am. 2012 Jun 20;94(12):1140-6.

What's new in spine surgery. Bridwell KH, Anderson PA, Boden SD, Vaccaro AR, Wang JC. J Bone Joint Surg Am. 2011 Aug 17;93(16):1560-6.

Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor. Liu H, Liu Y, Viggeswarapu M, Zheng Z, Titus L, Boden SD. J Bone Miner Res. 2011 May;26(5):1122-32.

The influence of alendronate on spine fusion in an osteoporotic animal model. Nakao S, Minamide A, Kawakami M, Boden SD, Yoshida M. Spine (Phila Pa 1976). 2011 Aug 15;36(18):1446-52.

A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype. Kato S, Sangadala S, Tomita K, Titus L, Boden SD. Mol Cell Biochem. 2011 Mar;349(1-2):97-106.

Stromal cell-derived factor-1 potentiates bone morphogenetic protein-2 induced bone formation. Higashino K, Viggeswarapu M, Bargouti M, Liu H, Titus L, Boden SD. Tissue Eng Part A. 2011 Feb;17(3-4):523-30.

Do the adjacent level intervertebral discs degenerate after a lumbar spinal fusion? An experimental study using a rabbit model. Higashino K, Hamasaki T, Kim JH, Okada M, Yoon ST, Boden SD, Hutton WC. Spine (Phila Pa 1976). 2010 Oct 15;35(22):E1144-52.

What's New in Spine Surgery. Bridwell KH, Anderson PA, Boden SD, Vaccaro AR, Wang JC. J Bone Joint Surg Am. 2010 Aug 18;92(10):2017-28.

Surgical versus nonoperative treatment for lumbar spinal stenosis four-year results of the Spine Patient Outcomes Research Trial. Weinstein JN, Tosteson TD, Lurie JD, Tosteson A, Blood E, Herkowitz H, Cammisa F, Albert T, Boden SD, Hilibrand A, Goldberg H, Berven S, An H. Spine (Phila Pa 1976). 2010 Jun 15;35(14):1329-38.

2009 ISSLS Presidential Address: the three key questions. Boden SD. Spine (Phila Pa 1976). 2010 Apr 15;35(8):845-7.

The evidence-based approach in bringing new orthopaedic devices to market. Schemitsch EH, Bhandari M, Boden SD, Bourne RB, Bozic KJ, Jacobs JJ, Zdero R.J Bone Joint Surg Am. 2010 Apr;92(4):1030-7.

Osteoinductive LIM mineralization protein-1 suppresses activation of NF-kappaB and selectively regulates MAPK pathways in pre-osteoclasts. Liu H, Bargouti M, Zughaier S, Zheng Z, Liu Y, Sangadala S, Boden SD, Titus L. Bone. 2010 May;46(5):1328-35.